Differentiation Syndrome is a life-threatening complication of induction chemotherapy for patients with acute promyelocytic leukemia (APL). Manifistations of this syndrome include fever, hypoxemia, edema, and, in the past, has been referred to as "cytokine storm." How can the diagnosis of Differentiation Syndrome be captured? Does ICD-10 provide for this condition?
Linda Hinkley, RN, MSN
Page 928 , 2013 HEMATOLOGY BASIC PRINCIPLES AND PRACTICE
I know of no code so I would watch for MCC's of acute noncardiogenic pulmonary edema and acute respiratory failure requiring intubation and mechanical ventilation.
Its etiology is poorly understood. It is thought to be caused by a capillary leak syndrome induced by the rapid differentiation of leukemic promyelocytes.
Is it adverse effect of chemo?